Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis.

نویسندگان

  • Noton K Dutta
  • Michael L Pinn
  • Petros C Karakousis
چکیده

We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the "Denver regimen" against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 58 9  شماره 

صفحات  -

تاریخ انتشار 2014